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Similarly, the use of ebselen, a GPx mimetic, attenuates cerebral ischemia-reperfusion injury in GPx-1 / -deficient mice (392)

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On the other hand, treatment of cancer cells with the anti-IGF-IR mAb cixutumumab paradoxically triggers cancer cells to produce IGF2, which in turn recruits macrophages and fibroblasts to promote angiogenesis and metastasis thereby hampering the efficacy of cixutumumab [190]