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On average, trial patients lost 8.6% to 12.6% of their body weight, or 19.8 to 29.3 pounds, after 26 weeks of taking orforglipron, compared to 2%, or 4.6 pounds, among those administered the placebo

Murphy C, Murphy S, O'Brien F, O'Donoghue M, Boileau T, Sunvold G,