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This is precisely why the in-vivo studies that express the E-domain as part of an IGF-I isoform, rather than as a free fragment, are so valuable: they sidestep the assumption that a cleaved free peptide is the physiologically relevant species
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The launch of generic liraglutide (Teva, August 2025) and anticipated oral GLP-1 options (oral Wegovy approved December 2025, orforglipron pending) offer lower-cost alternatives that may simplify pharmacy benefit management