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Sources: 1 Binsaeed, Bayan et al

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If you've been taking semaglutide at a higher maintenance dose, dropping to a lower dose for 24 weeks, then to an even lower dose, prevents the appetite surge that happens with immediate cessation

Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X) Diabetes Care

Administration of GLP-2-2G-XTEN resulted in a significant increase in small intestine weight and length as well as reduced inflammation scores and proinflammatory cytokines (Alters et al

Current guidelines from the American Society for Metabolic and Bariatric Surgery recommend surgical evaluation for individuals with BMI 40 kg/m or BMI 35 kg/m with obesity-related comorbidities