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Unlike many other weight loss medications, retatrutide targets three incretin pathways, resulting in more robust energy balance control and appetite regulation

139 GLP-1RA presents two considerations regarding weight-related factors in MASLD

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HbA1c falls where it starts high, and the glucose effect saturates below the weight dose: doubling from 1.0 to 2.0 mg added only about 0.2 points of HbA1c while still adding weight loss

doi:10.1038/nsb0498-267

doi: 10.3390/ijms231710076 68 IshimotoTSugiharaHWatanabeMSawayamaHIwatsukiMBabaYet al