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IGF-1 LR3 is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-I is produced in response to GH and then induces cellular activities

Additional findings describe alterations in immune, stromal, and acinar cells, whose interactions with endocrine elements may substantially influence T2D pathogenesis

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Science 137 , 499508 (1962)

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The placebo group lost 2.4 percent