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Waist circumference improvements were also greater with the higher dose, with an average additional reduction of nearly 12 cm or 4.72 inches compared to placebo

Shared fibrogenic pathwaysincluding the TGF-HA/CD44STAT3 axisare activated across multiple organs in hypothyroid states (124)

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In addition, the FDA has recently identified potential safety issues based on reports of other rare non-GI side effects, such as hair loss and suicidal ideation

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Collectively, this body of work has reinforced interest in melanocortin pathways as adjunct research targets within infection and inflammation biology, offering mechanistic insight into immune modulation independent of conventional antimicrobial strategies [23,24]