Supplied as lyophilised powder for in-vitro research use only
Funding This study was supported by a Commercial Development & Industry Partnership (CDIP) grant (CT20584-University of Sydney and Whiteley Corporation) and a Department of Industry, Innovation and Science (Innovative Manufacturing CRC Ltd.) and Whiteley Corporation co-funded project grant A Novel Approach to Biofilm Disruption and Removal (IMCRC/WLY/08052019.1)
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A: Glutathione is a tripeptide composed of three amino acids: glutamate, cysteine, and glycine
R The key catalytic mechanism involves lowering the pKa of the glutathione thiol from 9.0 to approximately 6.5, generating the thiolate anion (GS) at physiological pH, which is a potent nucleophile