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To reduce iron overload, injection of deferoxamine, an iron chelator, into a murine endometriosis model decreased inflammation and limited lesion proliferation [17]

Histologically, epidermal thickening, severe hyperkeratosis, and epidermal acanthosis were seen ( Mll4 -knockout mice developed red, scaly skin ( Alox12 , Alox12b , and AloxE3 expressions were downregulated

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In another rodent experiment, synthetic TB4 was administered to models of autoimmune encephalomyelitis, markedly decreasing the number of inflammatory cells in the brains of the treated animals [39]