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Interestingly, Cyp7a1 expression in Insr P1195L/ +/HFD mice was markedly decreased by re-feeding (Fig

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In addition, co-culture experiments with cancer-associated fibroblasts (CAFs) and T cells revealed that CAFs could induce drug resistance, while microsatellite instability-high (MSI-H) tumors showed strong T cell-mediated cytotoxicity [33]