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Silica NPs could induce oxidative stress, inflammation, and NO/NOS system disorder, ultimately causing endothelial cytotoxicity by activating the MAPK/Nrf2 and NF-B signaling pathways ( 2 NPs induced the lung alveolar epithelial cell apoptosis by ROS-regulated PI3K/AKT-mediated mitochondria- and ER stress-dependent signaling pathways, leading to lung injury (Lee et al., 2020)

Therefore, recovery-associated anabolic pathways may be examined independently of glucocorticoid-driven counterregulation in laboratory settings

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They have a condition that makes them need extra folate Examples include certain types of anemia, pregnancy and skin diseases