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Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A

In metabolic regulation, Scrophularia -containing formulations (e.g., Clean-DM1) activate IRS/PI3K/AKT and AMPK signaling pathways, thereby improving insulin resistance and correcting glucose-lipid metabolic dysfunction (138)

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Acinar cell injury activates Nuclear factor-kappa B (NF-B), inducing transcription of pro-inflammatory mediators that recruit leukocytes into the pancreas [16]