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10.1177/1352458517711568 21 CobleyJ

Biochim Biophys Acta 226: 259268

Contributing factors include: A diet high in sugar and processed fats[1] Exposure to environmental toxins like air pollution, pesticides and heavy metals[2] Cigarette smoke[3] and alcohol use[4] Infections and chronic inflammation[5] Intense or prolonged physical exertion[6] Psychological stress[7] Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression

Glutamine is an amino acid that supports skin health by promoting collagen synthesis and aiding in cell regeneration and repair

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Sleep fragmentation induces AQP4 mislocalization from astrocytic endfeet, reducing CSF clearance efficiency