But what we wanted to understand is what theyre doing in the brain. Key findings GLP-1 drugs act not only on metabolic pathways but also on brain circuits linked to reward Researchers identified a pathway connecting the hindbrain, central amygdala and dopamine-producing neurons The drugs reduce not just hunger, but the desire for high-calorie, rewarding foods Findings may help explain both therapeutic benefits and side effects such as nausea or reduced pleasure Beyond appetite suppression GLP-1 receptor agonists were originally developed to treat Type 2 diabetes by improving insulin response, with weight loss emerging as a secondary benefit
Challenges: modifications are needed to ensure drug can be soluble and stabilized across a range of PH and mediums
The review will adhere to the methodology outlined in the Joanna Briggs Institute Reviewers Manual [2], and will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) [8]
Shant also provided their expertise and assistance with drug formulation for neuropharmacology experiments
In a candid interview on The Kelly Clarkson Show in May, Goldberg revealed that she used the GLP-1 medication Mounjaro, stating that she lost the weight of almost two people. Im doing that wonderful shot that works for folks who need some help, and its been really good for me, Goldberg told Clarkson
Their platform emphasizes understanding the challenges this stage of life brings
