J Prenat Med (2012) 13
The process begins with genetic susceptibility, primarily caused by high-risk HLA class II alleles (e.g., HLA-DQ2/DQ8), and is complemented by class I alleles and key non-HLA variants in immunoregulatory genes
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These proteins have been associated extracellularly with cancer, inflammatory disorders, autoimmune diseases, or cardiovascular diseases (CVD) and have been detected in diverse body fluids, including serum, urine, sputum, cerebrospinal fluid, and feces, from patients with these conditions [74,75,76,77,78,79]
Chen C, Matesic LE
