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When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice

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Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma