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If you are experiencing loose stools, the primary goal is to prevent dehydration and allow your gut to rest

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Those comparing retatrutide versus tirzepatide will want to factor digestive tolerance into their decision alongside efficacy data

Mean Insulin Secretion Rate Versus Glucose Concentration in Patients with Type 2 Diabetes during Graded Glucose Infusion before (Baseline) and after 12 Weeks of Treatment with Semaglutide or Placebo and in Untreated Healthy Subjects During induced hypoglycemia, semaglutide did not alter the counter regulatory responses of increased glucagon compared to placebo and did not impair the decrease of C-peptide in patients with type 2 diabetes

GLP-1 prevents more glucose from entering your bloodstream

But it does not seem to affect the number of naps needed, quality of life, or sleepiness