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it does not directly modulate systemic hormonal axes in research models

These components are considered immunological distractors with pro-inflammatory activity, capable of causing dysbiosis and increased intestinal permeability (the so-called leaky gut syndrome), so favoring the development of autoimmune diseases [142]

A caveat to both Gonzalez et al

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At variance, in a study focused on the antiaging effect of CR on mitochondria isolated from different rat tissues (brown adipose tissue, liver, heart, kidney, and brain), no significant effects of CR on state 4 mitochondrial respiration rate were found in all tissues, except for the brown adipose tissue, where state 4 was ~3-fold higher as compared to mitochondria from fully fed controls (Lambert et al., )

First, we used Jurkat cells to assess binding to CD3 and observed comparable binding to the CD3 Fab alone (Fig