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Invest 134 , e175265 (2024)

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics

10.1111/j.1365-2265.2008.03415.x 6 ArodaV

Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN -amplified neuroblastoma

From the outset, Smith was interested in asking the mechanistic questions to work out why some people respond to a particular drug and some dont. The EMI post allowed Smith to develop her own ideas and to take on her first role as Chief Investigator in a national study, looking at responses to vaccines in vasculitis patients