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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

Luckily, the liver is very resilient , and even if some degree of liver damage is experienced (either from overdoing it with Tylenol or from something else), the liver usually starts to recover within a couple days of stopping the drug and is fully back to normal within several weeks or months

doi: 10.1016/j.autrev.2020.102527

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.ElHajj C., Walrand S., Helou M., Yammine K