Most probably, the observation period of six months was too short to sensitively detect worsening in visual outcomes, including GCL volume loss, also proven by a recent study in which a delayed decline in visual field and GCL volume after 12 months was seen [39]
Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects-a randomised double-blind placebo-controlled clinical trial
Biochim Biophys Acta 1315 : 159162
According to MHRA product information for hydroxocobalamin (the standard injectable form used in the UK), common side effects include injection site reactions and occasional hypersensitivity reactions, but anxiety is not listed as a recognised adverse effect of B12 supplementation
The results of this study have a positive impact on medication safety for patients with type 2 diabetes or obesity, which is important in maintaining public health and providing strong support for clinical medication decisions
[13] [15] Other rare adverse effects include dizziness, headache, and fatigue