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Clinical trial criteria excluded a significant number of adults without diabetes eligible for GLP-1 receptor agonist treatment from studies assessing the drugs safety and efficacy, results of a research letter showed

For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]

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