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Human epicardial fat expresses glucagon-like peptide 1 and 2 receptors genes

Diabetes Care 38(7):12631273 Moller DE (2001) New drug targets for type 2 diabetes and the metabolic syndrome

This metabolic penalty persists for years and makes maintaining weight loss without pharmacological support extraordinarily difficult

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Native IGF-1 is largely captured by these proteins, which regulate how much free, active hormone is available