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The side effect profiles of GLP-1 agonists are dose-dependent

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(1967) A potentiation study in rats of Vapona with 26 other cholinesterase-inhibiting compounds, Menlo Park, California, Stanford Research Institute (Unpublished Report, 2 June)

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This alarms people, who reasonably interpret it as the medication losing effect, but it is what the trial data predicts and what a body settling at a new equilibrium looks like