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Several in vitro studies documented that an increased oxidative stress and an ROS could augment adipocyte proliferation, differentiation, and growth (2022), and control hunger and satiety behaviors (23)

Among these symptoms, lipid peroxidation is evident throughout the progression of DN, and the levels of the products of lipid peroxidation, namely, MDA and 8-iso-PGF2 can be indicators to judge or predict the degree of kidney injury in the early stage of DN

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