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In preclinical studies, the combination of PLK1 inhibitor Volasertib (intravenous injection, 30 mg/kg) and HDACi Belinostat (intraperitoneal injection, 50 mg/kg) significantly inhibited tumor growth in a DLBCL/MCL mouse model by synergistically inducing DNA damage and downregulating c-Myc (104)

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and cerebral edema and seizures

BPC-157 Dosage by Body Weight Most published protocols use a flat dose rather than a strict mg-per-kg formula, but bigger frames generally sit at the higher end of a given range