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The four-week hold per step is not arbitrary it matches the interval at which GI adverse events subside as the gut adapts

*Correspondence: Fateme Zare, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Comparative effects among GLP-1 RAs on microbiota Different GLP-1 RA drugs (liraglutide, exenatide, dulaglutide, semaglutide) appear to have broadly similar trends in microbiota modulation, though nuances exist

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