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A 10mg/ml vial contains 2.5mg in those 25 units

Any data beyond what is reported in the manuscript, including but not limited to the raw EHR data, cannot be shared or released due to the parameters of the expert determination to maintain the data de-identification

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As can be seen from the comparison between example 6 and comparative example 3, the procedure of comparative example 3 is complicated, the Boc-modified semaglutide propeptide is coupled with Fmoc complex (Fmoc-His-Aib), then Boc is removed, the simaglutide is coupled with a side chain with tert-butyl protection, then Fmoc is removed, and finally tert-butyl is removed to obtain semaglutide, the whole process requires 5 steps, frequent deprotection (3 times of deprotection) causes racemization of some amino acids and generation of deletion peptide, especially racemization of terminal His and introduction of other impurities with incomplete Fmoc removal, which causes great difficulty in subsequent purification

Bariatric surgery may reduce knee pain in persons with obesity, although data from randomized, controlled trials are lacking

The fourteenth embodiment of the present invention provides a process for the purification of compound of forumula-13, comprising subjecting a solution of compound of formula- 13 to RP-HPLC purification by using acetonitrile as mobile phase