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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

Alfenito MR, Souer E, Goodman CD, Buell R, Mol J, Koes R, Walbot V 1998 Functional complementation of anthocyanin sequestration in the vacuole by widely divergent glutathione S-transferases

& Varmus, H

Compound: 5-Amino-1MQ

Compounding pharmacies involved in the preparation of synthetic peptides must adhere to stringent protocols to safeguard the integrity of these research materials

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