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Separate neuron populations within the arcuate nucleus express the precursor of the melanocortin receptor agonist proopiomelanocortin (POMC) and the melanocortin receptor inverse agonist agouti-related protein (AgRP)

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Due to the compounds plasma half-life of approximately 3.86.9 hours [4] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

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