The next step involves the enzyme glutathione synthetase, responsible for adding glycine to the dipeptide to produce GSH (-glutamylcysteinylglycine) and also requires coupled ATP hydrolysis (Meister, 1974)
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R Clinical genetics resources: PharmGKB (pharmacogenomics knowledge base): pharmgkb.org CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines for UGT1A1, NAT2, TPMT: cpicpgx.org Conjugation pathway substrates and testing: The Hepatic Detox Profile (caffeine/aspirin/acetaminophen challenge) is the gold standard functional test for Phase I/II conjugation capacity in clinical practice
Fatigue, weight loss, or other unexplained symptoms
doi: 10.1093/biolre/ioaa194 7 RaKParkSCLeeBC
