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10.1111/cns.13730 CNS Neurosci

Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice

The initial loading dose phase is crucial here, providing that quick surge of B12 to help address the neurological effects

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If you dont see results after reaching an adequate dose with proper adherence, talk to your provider about alternatives switching to weekly injection, adding the Precision Peptide Genetic Test for a GLP1R/GIPR baseline, or escalating to a dual-agonist option like PlexusDx GLP-Squared