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J., Keinnen, T., Sinervirta, R., Herzig, K

In the intrinsic pathway, mitochondrial membrane permeabilization allows cytochrome c to enter the cytosol, forming the apoptosome with APAF-1 and caspase-9, which then activates caspase-3, leading to nuclear fragmentation, protein degradation, and chromatin condensation [32]

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Ann Rehabil Med