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In addition to activating the GLP-1 receptor, it also stimulates the GIP receptor, which plays a role in fat metabolism and energy balance

This is important in identifying early patients that could require a more intensive intervention. Most weight loss retained long term In the first post hoc analysis, researchers assessed data from 690 participants in the SURMOUNT-1 3-year study who lost at least 5% of their body weight (mean age, 49 years

While found throughout the body, its more prominent in the liver and in fat cells

Because semaglutide has a prolonged half-life (approximately 1 week) and lacks definitive safety data in pregnancy, it is not recommended for women attempting to conceive [19]

Older options: Phentermine, Contrave