Exposure to high temperatures (above the recommended limits) can cause the protein structure to denature or break down, reducing the medication's potency
CRC Press Bsoul SA, Terezhalmy GT (2004) Vitamin C in health and disease
But by staying calm during a cold shower, or a cold bath, you can train your Vegas nerve in a very similar way, actually, as another strategy I talk about in the book: Staying calm during hard exercise
Epithalon regulates pineal gland function and melatonin secretion, supporting deeper, more restorative sleep and healthy circadian rhythm alignment for optimal recovery and hormone balance
It needs to be noted that all the measurements were done at rest
(PubMed) Stephenson CM, Levin RD, Spector T, Lis CG