PMID: 8637402 Feeding-Behavior Research (MC3R/MC4R, Rodent Models) Central MC3R/MC4R-mediated food intake reduction in rats Beckman, Levine, and Billington ( Physiol Behav , 2009, PMID 19136019) and Trivedi and colleagues ( Brain Res , 2003, PMID 12834882) reported that central MC3R/MC4R agonism by Melanotan II decreased food intake in rodent models
In four randomized controlled trials (RCT) conducted in patients with obesity without T2D 15,16,17,18 , liraglutide 3.0 mg was compared to placebo as an adjunct to lifestyle optimization over 56 weeks, with the exception of the 3-year extension of the SCALE Obesity and Prediabetes study
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London: IntechOpen (2024)
Acknowledgements We thank Kayoko Kagaya and Hiromi Fujishima for excellent technical support
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