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Most participants reached their target dose between weeks 8 and 12

This work was supported by the JSPS KAKENHI: 21H02727 for S.N

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Once your system stabilizes, you can gradually introduce a low-fermentation prebiotic like acacia fiber if you want microbiome support

Overcoming these challenges will require advanced delivery platforms such as nanoparticles or hydrogels, personalized stratification tools such as lipidomic and ncRNA signatures, and rigorous pharmacokinetic validation in long-term OA models

Glucagon-like Peptide-1 receptor agonists and risk for suicidal ideation and behaviors in U.S