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Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke

High-fat or WD has equivocal effects on hippocampus-based memory tasks (7784), however in tasks using amygdala-based memory task, male mice were found to have selectively impaired cued fear memory in response to diet exposure (85), consistent with our results, or finding no significant impact of WD on hippocampus-dependent memory tasks (83,84)

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