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3.1.2 ATIC polymorphism ATIC gene is located at chromosome 2q35 and encodes aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) that participates in the de novo purine synthesis and transforms aminoimidazole carboxamide adenosine ribonucleotide (AICAR) into formyl- AICAR

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Patients with severe renal or hepatic impairment require careful dose adjustment and monitoring

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