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Likewise, endothelial cells are regulating mucosal immune homeostasis, acting as "gatekeepers", controlling leukocyte accumulation in the interstitial compartment

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This increased tolerance results from the brain adapting to opioid exposure, reducing its responsiveness to the drug

Cribioli E, Giordano Attianese GMP, Ginefra P, Signorino-Gelo A, Vuillefroy de Silly R, Vannini N, et al

Nature 603, 672678