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This autophosphorylation event serves as the first signal that propagates through multiple intracellular pathways

Accessed June 17, 2025.

Results of a study of 203 sarcomas, 50 carcinomas and 28 malignant melanomas

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Its involvement in tumor development and treatment is complex, influenced by oncogenes, tumor suppressors, and the tumor microenvironment ( + T cells ( Figure 1 Beyond cancer, mounting evidence suggests that iron dysregulation, oxidative stress, and GPX4 suppression are key features of ferroptosis in neurodegenerative diseases and cognitive impairments