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Side Effects: How They Compare Both drugs share a very similar side effect profile because both act on the GLP-1 receptor

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Notably, more than 30% of patients dropped out of treatment after the first month

Kidney infections, pyelonephritis, are serious and can require hospitalization, intravenous antibiotics, and temporary discontinuation of semaglutide to manage dehydration risk

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Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes