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Furthermore, in the absence of tryptophan, neoantigens generated by the substitution of this amino acid for phenylalanine in proteins can be targeted by T cell-mediated immune responses [155]
Patients are carefully monitored to manage tolerability and ensure that treatment remains appropriate and safe
More serious risks include pancreatitis, gallbladder disease, acute kidney injury with dehydration, suicidal ideation, and potential thyroid C-cell tumors (observed in rodent studies, though human relevance remains uncertain)
Nurchi et al (2020) also focus on the sources of human exposure to environmental arsenic such as drinking water, food and occupational exposure
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