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Electrophysiology experiments further demonstrated that GLP-1R activation led to depolarization of POMC neurons and inhibition of NPY/AgRP neurons, mediated by GABAergic signaling, explaining the suppression of hunger signals

It mimics the natural GLP-1 hormone, released in the gut in response to eating

While this does not typically cause weight plateaus, the associated symptoms like anxiety, insomnia, and digestive changes can interfere with your meal planning and dietary compliance

Weight Cycling and Long-Term Dependency Another problem is that GLP-1s are not designed for intermittent use

Resistance exercise: Pairing protein intake with strength training at least twice per week signals the body to preserve lean mass during weight loss

You can take Tradjenta with or without food