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CVS announced that this change will probably force thousands of patients to switch from Lillys Zepbound (tirzepatide) ( [61] )

Intestinal stem cells The homeostasis of intestinal epithelial cells is dependent on the continuous self-renewal capacity of crypt intestinal stem cells (ISCs), particularly Lgr5+ stem cells located at the base of the crypt, which proliferate and differentiate into various epithelial lineages to maintain mucosal integrity and barrier function 20