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By inhibiting this pathway, DIM decreases the production of proinflammatory cytokines such as TNF- and IL-6, as well as prostaglandins

The imaging tools have done that

At a dose of 300 mg, it can cross the blood-brain barrier, directly increasing the synthesis of acetylcholinea neurotransmitter pivotal for learning and memory

Some researchers suggest that acute spikes in plasma glucose trigger this stress (Papachristoforou et al., 2020), while others attribute it to glycemic variability (Rehman and Akash, 2017)