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Existe evidencia sobre cambios en la microbiota intestinal en pacientes que se encuentra bajo tratamiento con iSGLT2, pero no existe evidencia que respalde una asociacin con efectos adversos gastrointestinales5,43,44

The SELECT trial (NEJM, 2023) showed a 20% reduction in major cardiovascular events in patients taking semaglutide

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Unlike the rapid recruitment mechanism seen in -cells, GLP-1 promotes organelle coupling in VSMCs through the PKA-dependent transcriptional up-regulation of MFN2

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Preserving lean muscle mass Improving insulin sensitivity Supporting cardiovascular and mental health Sagging skin Muscle loss Fatigue or lowered metabolic rate Visual Snapshot : GLP-1 weight-loss treatments , fitness guidance, and body-contouring strategies to support healthier and more sustainable results