.8 mg semaglutide Ozempic 8 mg/3 mL (2.68 mg/mL) prefilled pen that delivers 2 per injection Images Semaglutide Weight Loss Dosage Chart:

There are many potential/partial explanations for this difference: Tirzepatide is a dual agonist (for GIP/GLP-1), making it an arguably more structurally complex molecule and less tenable for recombinant expression (though both are linear peptides with a side chain)

That 20% matters more than it sounds

One study from 2019 found that exercise therapy had a significant effect on reducing constipation symptoms in participants

One common side effect reported by some patients is dry mouth, also known as xerostomia

Covariate effects were limited to effects on clearance

But it is an important consideration, given that the research published so far shows that when patients discontinue using these medications, their appetite returns, and the majority regain some or all of the weight they initially lost