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Modern translational frameworks emphasize combination therapy, biomarker-guided dosing, and behavioral stratification, all of which may improve the therapeutic index of appetite-regulating peptides

For example, those with chronic kidney, liver, or heart conditions may experience excess fluid retention, or edema

Tirzepatide is a novel medication that acts as a dual agonist of the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) receptors

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Many HR genes are S phase regulated, but we saw no differences in S phase in IDH1-inhibited or TMLHE-knockdown cells (Extended Data Fig

L.OconnorM.DenenbergA.HakeP.ZingarelliB