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Specific FDA concerns: Increased heart rate, systemic vasodilatory reactions, limited clinical safety data, immunogenicity risk

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Aroda, Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial

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Growth Factor Expression Upregulates TGF-b, FGF, and EGF growth factors that stimulate cell proliferation, collagen synthesis, and extracellular matrix remodeling to rebuild damaged tissue